The anticipated growth of (motorized) mobility on a global scale will, without effective road safety management, lead to an increase in the number of fatal accidents and injured persons. An overview of prominent examples of effective measures is given. Also activities and measures which could lead to a further reduction in road casualties are described. However, it is not to be expected that one single all-embracing measure can be found to solve the problems. It is rather more the necessity to carry out existing measures and activities in a better way based on synergy and permanent implementation. Indeed, at an early stage of planning and investment in road infrastructure (construction and maintenance), preventive and explicit road safety actions need to be undertaken. Of importance is the setting of political priorities, adequate organization and sufficient budgets. The international exchange of know-how on effective measures, for example via meta-analyses and `best practice' overviews, could be of help and to this end. The international road safety community is encouraged to take initiatives to develop co-operation.